Plastic Surgery Update on the Mesenchymal Stem-Cell Derived Extracellular Vesicles towards Cell-Free Therapeutic Applications

The document discussed the potential of mesenchymal stem-cell derived extracellular vesicles (EVs) in plastic surgery as a cell-free therapeutic application. EVs, which include exosomes, are released from stem cells and contain growth factors, cytokines, and bioactive molecules that facilitate various cellular processes such as immune signaling and tissue repair. Plastic surgeons showed interest in EVs for their potential in cell repair, tissue engineering, and aesthetic rejuvenation. Although preclinical and clinical experiences were promising, further research was needed to clarify product identification, biological functions, and standardized protocols to ensure safe and effective clinical outcomes. The document emphasized the importance of advancing evidence-based stem cell studies in compliance with FDA regulations.