Photo-Cross-Linked and Photothermal Flammulina Velutipes Polysaccharide Hydrogel Loaded with Caffeic Acid-Copper Nanozyme for Diabetic Wound Healing

The study presents a novel photo-cross-linked Flammulina velutipes polysaccharide hydrogel combined with caffeic acid-copper nanozyme (FVP@CCN) for diabetic wound healing. This hydrogel exhibits rapid degradability, tunable mechanical properties, and intrinsic antimicrobial activity, along with excellent biocompatibility. The incorporated nanozyme enhances photothermal antimicrobial ability, ROS scavenging, angiogenesis promotion, and pH-responsive release of active components. In vivo studies showed that FVP@CCN effectively addresses multiple healing impairments in diabetic wounds, achieving over 90% wound closure within 7 days, and promoting hair follicle regeneration. This multifunctional hydrogel offers significant potential for diabetic wound treatment and can be adapted for other plant-based polysaccharide hydrogels.