Patient-Centered Combination Therapies for Hair Restoration: Synergistic Mechanisms of Platelet-Rich Plasma and Microneedling, Personalized Approaches, and Evidence-Based Outcomes

The combination of Platelet-Rich Plasma (PRP) and microneedling is a promising and effective treatment for androgenetic alopecia (AGA), significantly improving hair density and thickness with high patient satisfaction rates (82%-91%). This therapy enhances growth factor delivery and stimulates healing pathways, with a favorable safety profile and fewer pain-related complaints compared to PRP alone. However, challenges such as variability in PRP preparation and small sample sizes remain. Future research should aim for large-scale, standardized trials and personalized approaches to optimize outcomes and establish guidelines.