Chronic Telogen Effluvium and Female Pattern Hair Loss Are Separate and Distinct Forms of Alopecia: A Histomorphometric and Immunohistochemical Analysis

August 2014 in “ Clinical and Experimental Dermatology ”

Carla Bittencourt, D. A. Ferraro, Taís Cristina Bastos Soares, Arthur Moraes, Maria Letícia Cintra

chronic telogen effluvium female pattern hair loss alopecia histomorphometric analysis immunohistochemical analysis telogen release cycle synchronization anagen follicular mitotic rates hair miniaturization CTE FPHL

Studysummary This study found that chronic telogen effluvium is a distinct condition from female pattern hair loss, with different pathogenic mechanisms observed in histomorphometric analyses.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study aimed to differentiate between chronic telogen effluvium (CTE) and female pattern hair loss (FPHL) through histomorphometric and immunohistochemical analysis. The results showed that CTE is a distinct disorder from FPHL, with different pathogenic mechanisms. CTE is related to immediate telogen release, leading to cycle synchronization, while FPHL is related to accelerated anagen follicular mitotic rates, resulting in hair miniaturization. The study adds to the understanding of the pathogenesis of these conditions, which is important for therapeutic tests.

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Research cited in this study

13 / 13 results

research Chronic Telogen Effluvium Is Due to a Reduction in the Variance of Anagen Duration

40 citations , May 2010 in “Australasian Journal of Dermatology”

This study suggests that chronic telogen effluvium may be due to a reduction in the variance of anagen duration, resulting in recurrent hair shedding with minimal long-term hair volume loss.

research Follicular Miniaturization in Female Pattern Hair Loss: Clinicopathological Correlations

100 citations , June 2006 in “British Journal of Dermatology”

This study found that as hair loss severity increased in women with female pattern hair loss, the number of vellus follicles also rose, indicating miniaturization of terminal hair follicles.

research Female Pattern Hair Loss and Its Relationship to Permanent/Cicatricial Alopecia: A New Perspective

73 citations , November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

This article reviews the potential relationship between different forms of permanent hair loss such as cicatricial pattern hair loss and discusses related conditions, reporting no new clinical findings.

research A Comparison of Vertical Versus Transverse Sections in the Evaluation of Alopecia Biopsy Specimens

56 citations , July 2005 in “Journal of The American Academy of Dermatology”

This study found that vertical sections of alopecia biopsy specimens had a higher concordance rate with the original combined diagnosis compared to transverse sections alone, although both methods have their pros and cons.

research The Reliability of Horizontally Sectioned Scalp Biopsies in the Diagnosis of Chronic Diffuse Telogen Hair Loss in Women

137 citations , July 2004 in “Journal of The American Academy of Dermatology”

This study observed that triple horizontal scalp biopsies provided a more accurate diagnosis of female pattern hair loss in women than a single horizontal biopsy, especially for those with advanced hair loss.

research Female Pattern Hair Loss

86 citations , July 2002 in “Clinical and Experimental Dermatology”

This review discusses female pattern hair loss, emphasizing its complex causes and the limited treatment options available, and reports no new clinical results.

research Androgenetic Alopecia in Men and Women

77 citations , March 2001 in “Clinics in Dermatology”

This article discusses treatment approaches for female pattern hair loss and concludes that available medical treatments are effective in reversing or stabilizing the condition in most cases of mild-to-moderate severity.

research Teloptosis: A Turning Point in Hair Shedding Biorhythms

56 citations , January 2001 in “Dermatology”

This study introduces the concept of teloptosis, which influences hair shedding during the telogen phase and affects hair density, highlighting that early or delayed teloptosis has noticeable effects.

research Chronic Telogen Effluvium: Potential Complication for Clinical Trials in Female Androgenetic Alopecia?

6 citations , December 1997 in “Journal of The American Academy of Dermatology”

CTE can distort results in hair growth trials, so exclude it carefully.

research Chronic Telogen Effluvium: Increased Scalp Hair Shedding in Middle-Aged Women

234 citations , December 1996 in “Journal of The American Academy of Dermatology”

The authors concluded that chronic telogen effluvium in middle-aged women presents distinct clinical and histological features that differ from androgenetic alopecia and acute telogen effluvium.

research Chronic Telogen Effluvium

75 citations , October 1996 in “Dermatologic Clinics”

This review examines chronic telogen effluvium, highlighting its distinctive features and the need for reassurance about its non-progressive nature, but reports no new clinical results.

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47 citations , May 1995 in “Journal of Investigative Dermatology”

Hair follicles in people with alopecia have lower levels of a key blood vessel growth protein.

research Telogen Effluvium: A Comprehensive Review

214 citations , March 1993 in “Archives of Dermatology”

This article proposes five different mechanisms for telogen effluvium, supported by clinical findings, based on changes in different phases of the hair cycle.