Rizatriptan Benzoate-Loaded Dissolving Microneedle Patch for Management of Acute Migraine Therapy
March 2024
in “
Journal of Biomaterials Applications
”
Studysummary This study developed dissolving microneedles using specific polymers for transdermal delivery of rizatriptan benzoate, demonstrating improved drug skin penetration and significant alleviation of migraine symptoms in vivo compared to passive diffusion, suggesting potential advantages over conventional treatment methods for acute migraine.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This study developed dissolving microneedles (MNs) using polyvinyl alcohol and poly (1-vinylpyrrolidone-co-vinyl acetate) for transdermal delivery of rizatriptan benzoate (RB) to treat acute migraines. In-vitro permeation studies and Franz diffusion cells demonstrated that these MNs enhance transdermal flux by effectively penetrating the skin. In-vivo pharmacological studies showed that RB-loaded MNs significantly alleviated migraine symptoms by modulating levels of 5-hydroxytryptamine, calcitonin gene-related peptide, and substance P. The study concludes that RB-loaded dissolving MNs offer safety, convenience, and high efficacy, supporting their potential as a transdermal drug delivery system for acute migraine treatment.
