Increased Androgen Bioavailability Is Associated With Non-Alcoholic Fatty Liver Disease In Women With Polycystic Ovary Syndrome

November 2009 in “ Human Reproduction ”

Evangeline Vassilatou, Sophia Lafoyianni, Andromachi Vryonidou, Dimitrios Ioannidis, L. Kosma, Konstantinos Katsoulis, Efstathios Papavassiliou, Ioanna Tzavara

androgen non-alcoholic fatty liver disease polycystic ovary syndrome sex hormone-binding globulin HDL cholesterol Free Androgen Index hyperandrogenism hepatic steatosis metabolic syndrome NAFLD PCOS SHBG HDL FAI

Studysummary This study found that women with polycystic ovary syndrome have a higher prevalence of non-alcoholic fatty liver disease and increased androgen bioavailability may be involved alongside metabolic factors.

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Research cited in this study

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research Polycystic Ovary Syndrome: Comprehensive Overview and Diagnostic Criteria

989 citations , August 2007 in “The Lancet”

This article reviews the clinical features, diagnostic criteria, and possible genetic and environmental influences of polycystic ovary syndrome but provides no new research findings.

research Abdominal Fat Quantity and Distribution in Women with Polycystic Ovary Syndrome and Its Relation to Insulin Resistance

270 citations , April 2007 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that PCOS patients had higher amounts of central abdominal fat compared to weight-matched controls, which was associated with increased insulin resistance.

Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline

1744 citations , August 2006 in “The Journal of Clinical Endocrinology and Metabolism”

This review discusses definitions of polycystic ovary syndrome and reports no new clinical results; the authors support using modified 1990 NIH criteria and acknowledge ongoing evolution as research advances.

research Prevalence of Polycystic Ovary Syndrome in Unselected Black and White Women of the Southeastern United States: A Prospective Study

378 citations , September 1998 in “The Journal of Clinical Endocrinology and Metabolism”

This study found that the prevalence of PCOS in a population of unselected U.S. women was 4.0%, with no significant racial differences between White and Black women.