Comparison of Treatment with Oral Vitamin D Alone, Topical Minoxidil, or Combination in Female Pattern Hair Loss

A study conducted at Sheikh Zayed Hospital Dermatology Department in Lahore with 81 female patients compared the effectiveness of treatments for female pattern hair loss (FPHL) using oral vitamin D, topical minoxidil, or a combination of both. The study found that the combination therapy (Group 1), which included 2% topical minoxidil and oral vitamin D, resulted in the most significant improvement in hair density and serum vitamin D levels, with levels increasing from 15.4+9.03 to 191.9+10.2 (P<0.001). Groups receiving only minoxidil (Group 2) or only vitamin D (Group 3) showed modest increases in vitamin D levels. The results suggest that the combination treatment is more effective, as minoxidil helps counteract hair follicle miniaturization and vitamin D addresses deficiency.