Using Patient Preference to Inform Ritlecitinib Dose Selection for Alopecia Areata Treatment

    January 2025 in “ The Journal of Dermatology
    Brett Hauber, Chiara Whichello, Jonathan Mauer … Robert Wołk
    Studysummary This study found that patients with severe alopecia areata are willing to accept increased risks of serious infection, cancer, and blood clots when opting for a higher dose of ritlecitinib, valuing the potential for greater hair regrowth efficacy compared to a lower dose.
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    Research cited in this study 7

    1. Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program American journal of clinical dermatology · 2024
    2. Treatment Preferences of Adults and Adolescents with Alopecia Areata: A Discrete Choice Experiment Journal of dermatology · 2023
    3. Efficacy and Safety of Ritlecitinib in Adults and Adolescents With Alopecia Areata: A Randomised, Double-Blind, Multicentre, Phase 2b–3 Trial The Lancet · 2023
    4. Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
    5. Evaluation of Stigma Toward Individuals With Alopecia JAMA Dermatology · 2021
    6. JAK Inhibitors and Alopecia Areata Lancet · 2019
    7. The Autoimmune Basis of Alopecia Areata: A Comprehensive Review Autoimmunity reviews · 2014

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    1. Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child International journal of research in dermatology · 2019