TLDR Biodegradable microparticles help wounds heal without scars.
The study investigated the use of biodegradable polymeric microparticles to achieve scarless wound healing in a murine model of deep skin wounds. Two types of microparticles, fibroin/gelatin and spidroin, were characterized and found to increase re-epithelialization rates and inhibit scar formation. Both types reduced the expression of profibrotic factors Fgf2 and Ctgf in mouse embryonic fibroblasts. However, only fibroin/gelatin microparticles induced a transient inflammatory response, attracting inflammatory Ly6C+ myeloid cells to the injection site. This suggests that microparticle carriers with similar regenerative potential could be adapted for treating wounds with varying levels of bioburden and fibrosis.
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