Non-Invasive Monitoring of Low Molecular Weight Biomarkers Relevant to Skin Inflammation and Cancer

This doctoral thesis explores non-invasive methods for monitoring low molecular weight (LMW) biomarkers relevant to skin inflammation and cancer. The research focused on hydrophilic biomarkers such as reactive oxygen species (ROS) and specific amino acids (tryptophan, kynurenine, phenylalanine, and tyrosine). Through a series of in vitro and in vivo experiments, the study demonstrated that these biomarkers can be collected from the skin surface, primarily through hair follicle pathways. The findings suggest that the phenylalanine/tryptophan ratio could serve as a reliable biomarker for skin disorders, providing a foundation for future clinical studies on non-invasive diagnostics.