Nitrogen Mustard Induces DNA Damage and Structural Changes in Mouse Skin Hair Follicles

April 2015 in “ The FASEB Journal ”

Gabriella Composto, Sally Kim, Diane E. Heck, Jeffrey D. Laskin, Debra L. Laskin, Laurie B. Joseph

nitrogen mustard DNA damage hair follicles sebaceous glands pilosebaceous units sebum production cellular division differentiation wound healing

TLDR Nitrogen mustard causes DNA damage and structural changes in mouse skin hair follicles, but some recovery occurs after 5 days.

The study investigated the effects of nitrogen mustard (NM) on hair follicles and sebaceous glands in mouse skin. Female CD-1 mice were exposed to NM, and changes were observed over 5 days. Initially, there was a decrease in markers for sebum production, cellular division, and differentiation, along with evidence of DNA damage. By day 2, an eschar formed with reduced pilosebaceous units and increased DNA damage markers. By day 3, these markers began to recover at the wound edge. By day 4, small pilosebaceous units showed increased expression of recovery markers, and by day 5, wound healing was evident with increased expression of these markers and decreased DNA damage. The study concluded that the pilosebaceous unit was a significant target in NM-induced skin injury.

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