Nitrogen Mustard Induces DNA Damage and Structural Changes in Mouse Skin Hair Follicles

April 2015 in “ The FASEB Journal ”

Gabriella Composto, Sally Kim, Diane E. Heck, Jeffrey D. Laskin, Debra L. Laskin, Laurie B. Joseph

nitrogen mustard DNA damage hair follicles sebaceous glands pilosebaceous units sebum production cellular division differentiation wound healing

TLDR Nitrogen mustard causes DNA damage and structural changes in mouse skin hair follicles, but some recovery occurs after 5 days.

The study investigated the effects of nitrogen mustard (NM) on hair follicles and sebaceous glands in mouse skin, revealing that NM exposure led to significant DNA damage and structural changes. After exposing female CD-1 mice to NM, researchers observed decreased expression of markers for sebum production, cellular division, and differentiation in the pilosebaceous units, along with increased DNA damage markers. Over 5 days, initial damage included reduced pilosebaceous units and increased DNA damage, but signs of recovery were evident by day 5, with increased expression of markers associated with wound healing. The findings suggested that the pilosebaceous unit was a critical target in NM-induced skin injury.

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