Nitrate Promoting Hair Growth Through Enhancing Wnt/β-Catenin and Downregulating TGF-β/Smad/BMP Signaling Pathway in C57BL/6 Mice

November 2024 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Yanjie Lan, Shenglan Li, Jiachen Wang, Ling Duan, Mengqian Huang, Xin Yang, Chunmei Zhang, Songling Wang, Wenbin Li

nitrate Wnt/β-catenin TGF-β hair follicle dermis Wnt3a β-catenin TGF-β1/Smad/BMP Fgf Igf-1 Vegf alopecia hair growth hair loss alopecia treatment

TLDR Nitrate can boost hair growth by activating certain pathways and reducing others.

This study investigated the effects of nitrate on hair growth in C57BL/6 mice, revealing that 10mM nitrate supplementation significantly promoted hair growth by increasing hair follicle numbers and dermis thickness. The mechanism involves enhanced expression of Wnt3a and β-catenin, along with reduced TGF-β expression. Additionally, nitrate increased levels of growth factors such as Fgf, Igf-1, and Vegf. These findings suggest that nitrate could serve as a potential therapeutic agent for preventing and treating alopecia by activating the Wnt/β-catenin pathway and inhibiting the TGF-β1/Smad/BMP signaling pathway.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 10 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Creatine Does Not Increase DHT And Does Not Cause Hair Loss - Randomized Controlled Trial

in Research/Science 307 upvotes 4 months ago

Creatine does not increase DHT levels or cause hair loss. Personal experiences vary, but scientific evidence shows no link between creatine and hair loss.

community 16 months finasteride progress but slowly losing hair again

in Progress Pictures 140 upvotes 6 months ago

A 21-year-old male experienced initial success with finasteride for 16 months but is now losing hair again. He is considering switching to dutasteride and adding oral minoxidil, while also investigating environmental and health factors.

community DHT Isn't (Directly) Important

in Research/Science 100 upvotes 6 months ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 2 upvotes 8 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 8 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

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Garlic can help hair grow by activating certain growth pathways, and it works whether you eat it or apply it to your scalp.

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Comparison of In Vitro Hair Growth Promotion and Anti-Hair Loss Potential of Thai Rice By-Product from Oryza Sativa L. Cv. Buebang 3 CMU and Sanpatong

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Et-BB3-CMU rice bran extract may be a promising natural option for promoting hair growth and preventing hair loss.