New Drugs: Iobenguane Sulfate

    October 2004 in “ Australian Prescriber ”
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    TLDR Lifestyle changes are more effective than metformin in reducing type 2 diabetes risk in women with PCOS.
    The document discussed the management of hirsutism and the long-term risks associated with insulin resistance, particularly in women with polycystic ovary syndrome (PCOS). It noted that while drugs like flutamide and finasteride were not commonly used in Australia due to potential side effects such as hepatotoxicity and teratogenicity, lifestyle changes were emphasized as more effective than metformin in reducing the incidence of type 2 diabetes, according to the Diabetes Prevention Program Research Group. There were no long-term clinical studies available to assess the cardiovascular benefits of metformin in women with PCOS.
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      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  55 upvotes 2 years ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community AA and Hirsutism but T levels are normal

      in Female  6 upvotes 4 years ago
      27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

      community Does low HGH leading to hairloss?

      in Research/Science  12 upvotes 1 year ago
      The user experiencing diffuse hair loss is using various treatments including RU58841, finasteride, minoxidil with tretinoin, anti-hair loss shampoo, and microneedling, and is considering adding peptides TB500, BPC157, and GHK-Cu. They have low growth hormone levels and are questioning its impact on hair loss, while another user suggests androgenic alopecia and androgens are likely the main cause of hair loss.

      community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

      in Progress Pictures  224 upvotes 1 year ago
      A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

      community Finasteride 5mg & Spironolactone 100mg

      in Female  2 upvotes 1 year ago
      A 20-year-old female is using finasteride 5mg and spironolactone 100mg for severe hirsutism and is experiencing minor side effects like water weight loss and irregular periods. She is concerned about potential future side effects and hair regrowth on her scalp.

      community No, Finasteride as a treatment for MPB was not an "accident"

      in Research/Science  108 upvotes 4 years ago
      Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

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