TLDR Growth hormone therapy can improve growth in Netherton syndrome patients with growth hormone deficiency.
Netherton syndrome (NS) is a rare genetic disorder characterized by skin scaling, hair abnormalities, and atopic features, caused by mutations in the SPINK5 gene leading to LEKTI deficiency. Growth retardation is common in NS, but growth hormone (GH) deficiency and its treatment had not been documented. The study reported three patients with NS who experienced growth retardation due to GH deficiency and showed positive responses to GH therapy. It was suggested that LEKTI deficiency in the pituitary gland might lead to excessive processing of human GH, contributing to the growth issues observed in NS patients.
124 citations
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January 1995 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Netherton's syndrome is linked to high IgE levels and unique skin and hair symptoms, and may improve with ammonium lactate lotion and allergy management.
59 citations
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June 2008 in “Journal of The American Academy of Dermatology” The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.
9 citations
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August 2021 in “Journal of clinical medicine” Pili torti is a rare condition where hair is twisted and breaks easily, often linked to genetic disorders or other health issues.
36 citations
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August 2018 in “Dermatologic Clinics” Trichoscopy is a useful tool for diagnosing hair disorders without pulling out hair.
33 citations
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June 2016 in “Pediatric Dermatology” Some congenital hair disorders improve in childhood or with treatments like minoxidil and retinoids, while others like Netherton syndrome and trichothiodystrophy have a poor prognosis.
42 citations
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January 2007 in “Pediatric dermatology” Low-potency steroids can cause serious side effects in people with skin conditions like Netherton syndrome.
