Nanostructured Lipid Carriers Loaded with an Association of Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia
January 2021
in “Social Science Research Network”
TLDR The new treatment using tiny lipid carriers to deliver minoxidil and latanoprost directly to hair follicles shows promise for alopecia.
The study aimed to develop a safe formulation for alopecia treatment using nanostructured lipid carriers (NLC) that entrap a combination of minoxidil and latanoprost, targeting drug delivery to the hair follicles. The NLC produced were shown to efficiently entrap 86.9% of minoxidil and 99.9% of latanoprost. In vitro, the drug combination positively affected human primary epidermal keratinocytes, supporting cell proliferation, migration, and inducing the mRNA expression of MKI67 proliferation marker, and VEGF – a possible effector for minoxidil-mediated hair growth. The nanoformulation was well tolerated according to the HET-CAM and reconstructed human epidermis assays. Drug penetration was evaluated in vitro using porcine skin, indicating that the NLC could be deposited preferentially into the hair follicles, causing a considerable increase in the penetration of the two drugs in such structures, compared to the control. The results suggest that hair follicle-targeted delivery of the minoxidil and latanoprost combination is a promising alternative to treat alopecia.
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