Influence of the Alkylsulfonylamino Substituent Located at the 6-Position of 2,2-Dimethylchromans Structurally Related to Cromakalim: From Potassium Channel Openers to Calcium Entry Blockers?

    April 2014 in “ European journal of medicinal chemistry ”
    Xavier Florence, Vincent Desvaux, Eric Goffin … Philippe Lebrun
    Studysummary This study found that several newly synthesized dihydrobenzopyran compounds inhibited insulin secretion and had vasorelaxant activity, with some more potent than reference KATP channel activators, though compound 21 functioned as a Ca2+ entry blocker.
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    Research cited in this study 3

    1. Modulation of the 6-Position of Benzopyran Derivatives and Inhibitory Effects on the Insulin Releasing Process Bioorganic & Medicinal Chemistry · 2011
    2. Potassium Channel Therapeutics at the Bedside Journal of Molecular and Cellular Cardiology · 2005
    3. Novel and Established Potassium Channel Openers Stimulate Hair Growth In Vitro: Implications for Their Modes of Action in Hair Follicles Journal of Investigative Dermatology · 2005

    Related research 1

    1. Influence of the Alkylsulfonylamino Substituent Located at the 6-Position of 2,2-Dimethylchromans Structurally Related to Cromakalim: From Potassium Channel Openers to Calcium Entry Blockers? European journal of medicinal chemistry · 2014