Pan-Cancer Analysis of MicroRNA Expression Profiles Highlights MicroRNAs Enriched in Normal Body Cells as Effective Suppressors of Multiple Tumor Types: A Study Based on TCGA Database

    April 2022 in “ PLoS ONE
    Sharif Moradi, Aryan Kamal, Hamidreza Aboulkheyr Es, Farnoosh Farhadi, Marzieh Ebrahimi, Hamidreza Chitsaz, Ali Sharifi‐Zarchi, Hossein Baharvand
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    Studysummary This study identified a set of tumour-suppressive microRNAs (miRNAs), termed 'normomiRs', that are highly expressed in normal tissues but low in tumors, with miR-206 and miR-381 showing significant in vitro cancer inhibition, highlighting their potential for miRNA-replacement therapies across multiple cancer types.
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