Murine Hair Follicle Derived Stem Cell Transplantation onto the Cornea Using a Fibrin Carrier

    January 2018 in “ BIO-PROTOCOL ”
    Mindy K. Call, Ewa Anna Meyer, Winston W.‐Y. Kao, Friedrich E. Kruse, Ursula Schlötzer‐Schrehardt
    TLDR Hair follicle stem cells can be transplanted onto the eye using a fibrin carrier to help repair eye damage.
    The study explored the transplantation of hair follicle-derived stem cells onto the cornea of limbal stem cell-deficient mice using fibrin carriers. The fibrin gel supported cell attachment, migration, and proliferation. Over 5 weeks, fluorescent microscopy showed that the transplanted stem cells successfully integrated and differentiated into corneal epithelial cells. This suggested potential therapeutic applications for treating limbal stem cell deficiency.
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