Mouse Spermatogenesis Reflects the Unity and Diversity of Tissue Stem Cell Niche Systems

    Shosei Yoshida
    TLDR Mouse spermatogenesis shows that stem cells can behave flexibly and move widely in open environments.
    The study on mouse spermatogenesis highlighted the unique characteristics of spermatogenic stem cells (SSCs) within the testicular seminiferous tubules, which operated in an open niche microenvironment. Unlike closed niches where stem cells and ligands are localized, SSCs in an open niche exhibited high motility and a wide distribution of self-renewal ligands. These dynamics, characterized by flexible and stochastic fate behaviors, were suggested to be common across various tissue stem cells. The review aimed to explore the unity and diversity of tissue stem cell systems, focusing on differences in ligand distribution and stem cell motility.
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