An Experimental Study of Morphofunctional Features of Hair Follicles' Early Response in Cyclophosphamide-Induced Alopecia

September 2024 in “ Journal of Anatomy and Histopathology ”

O. V. Guseva, Т. В. Николаева, V. Polyakova, N.V. Sharapova

cyclophosphamide alopecia 3-β-methoxy-Δ18-oleanene miliacin hair follicles anagen stages dystrophic hair follicles

TLDR Miliacin helps damaged hair follicles grow new hair faster.

The study investigated the effects of 3-β-methoxy-Δ18-oleanene (miliacin) on hair follicles in cyclophosphamide-induced alopecia using 30 male C57BL/6 mice. The mice were divided into five groups, with group IV receiving topical applications of miliacin. Results showed that in group IV, hair follicles were mostly in early and middle anagen stages with minimal dystrophy, while groups III and V exhibited dystrophic hair follicles. The study concluded that miliacin accelerates the transition of damaged hair follicles through the hair cycle, promoting a new cycle of hair growth.

View this study on doi.org →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research A Clinical and Biological Guide for Understanding Chemotherapy-Induced Alopecia and Its Prevention

38 citations, September 2017 in “Oncologist”

Scalp cooling can help prevent chemotherapy-induced hair loss with a 50-90% success rate and is safe for patients.

research Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond?

30 citations, July 2017 in “BioEssays”

Activating NRF2 might help treat hair disorders by improving antioxidant defenses.

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations, June 2005 in “Journal of Investigative Dermatology”

The document concludes that assessing hair follicle damage due to cyclophosphamide in mice involves analyzing structural changes and suggests a scoring system for standardized evaluation.

Similar Research

5 / 796 results

research Chemistry, Pharmacology, and Therapeutic Potential of Decursin: A Promising Natural Lead for New Drug Discovery and Development

August 2024 in “Drug Design Development and Therapy”

Decursin shows promise for treating cancer, neuroprotection, inflammation, and hair loss.

research Eclipta Prostrata (L.) L. (Asteraceae): Ethnomedicinal Uses, Chemical Constituents, and Biological Activities

21 citations, November 2021 in “Biomolecules”

Eclipta prostrata is a medicinal plant that helps treat diseases, protects the liver and nerves, and promotes hair growth.

research Chemical Composition and Biological Activities of Essential Oils of Curcuma Species

205 citations, September 2018 in “Nutrients”

Essential oils from Curcuma species, like turmeric, have compounds that can fight inflammation, cancer, and bacteria, and can also stimulate hair regrowth in bald males.

research Melatonin Protects K15+ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes Against Paclitaxel-Induced Damage Ex Vivo

1 citations, September 2023 in “Journal of Investigative Dermatology”

Melatonin may protect hair follicle cells from damage caused by a chemotherapy drug.

research Addressing Androgenetic Alopecia: A Complex Disorder with a Multilateral Treatment Strategy

1 citations, February 2017 in “MOJ bioequivalence & bioavailability”

Treating hair loss effectively may require a multi-sided approach, using different treatments together, and topical treatments could be more effective and safer than oral ones.