Molecular Mechanisms Underlying Cashmere Quality Differences Between Jiangnan Cashmere Goats and Changthangi Pashmina Goats

May 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”

Gao Gong (12870371), Shijie Bi (12975037), Xin Liang (442470), Yu Ao (5680964), Feng Xu (89016), Yiming Sulaiman (21438503)

PI3K-Akt signaling pathway thermogenesis ECM-receptor interaction IGF1 IGF1R FGF5 KRT10 secondary hair follicle development

TLDR Cashmere quality differences between goat breeds are linked to specific genes and pathways.

This study investigated the molecular mechanisms responsible for cashmere quality differences between Jiangnan cashmere goats (JNCG) and Changthangi pashmina goats (CPG) by analyzing skin transcriptomic data from different hair follicle growth stages. A total of 4,942 differentially expressed genes (DEGs) were identified, with significant enrichment in the PI3K-Akt signaling pathway, thermogenesis, and ECM-receptor interaction. Key candidate genes such as IFG1, IGF1R, FGF5, and KRT10 were highlighted for their roles in secondary hair follicle development and cashmere quality formation. These findings provide a theoretical basis for the genetic improvement of cashmere goats.

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research Molecular Mechanisms Underlying Cashmere Quality Differences Between Jiangnan Cashmere Goats and Changthangi Pashmina Goats

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research Molecular Mechanisms Underlying Cashmere Quality Differences Between Jiangnan Cashmere Goats and Changthangi Pashmina Goats

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