The Influence of the MDR1 C3435T Polymorphism on Methotrexate Responsiveness in Rheumatoid Arthritis Patients

July 2020 in “ The Egyptian Journal of Hospital Medicine ”

Shahira Fathy El Fedawy, Abeer Shehab, Rania A. Abo‐Shady, Samah A. El-Bakry, Dina Ragab, Sara Salem, Nermeen Samy

methotrexate MDR1 C3435T polymorphism hair loss

TLDR The MDR1 C3435T polymorphism does not significantly affect methotrexate response in rheumatoid arthritis patients.

The study investigated the influence of the MDR1 C3435T polymorphism on methotrexate (MTX) responsiveness in 90 rheumatoid arthritis (RA) patients. The patients were categorized into MTX responders and non-responders based on their disease activity score (DAS28). The results showed no statistically significant difference in genotype or allele frequencies between the two groups. However, patients with the C allele were 1.65 times more likely to be non-responders compared to those with the T allele. Common adverse effects of MTX included gastrointestinal upset (31.1%) and hair loss (11.1%). The study concluded that there was no significant association between the MDR1 C3435T polymorphism and MTX responsiveness in the RA patients studied.

View this study on ejhm.journals.ekb.eg →

Discuss this study in the Community →

Related Community Posts Join

3 / 3 results

community Why isn't anyone using Way-316606? If it works then it grows a full head of hair back on most people

in Treatment 134 upvotes 9 months ago

Way-316606 is considered a potential hair loss treatment but is avoided due to safety concerns and lack of research. Minoxidil and Finasteride are preferred as established treatments.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 1 year ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

Similar Research

5 / 1000+ results

research Absorption Sites of Orally Administered Drugs in the Small Intestine

55 citations , September 2017 in “Expert Opinion on Drug Discovery”

Different factors affect where drugs are absorbed in the small intestine, which is important for effective medication use.

research Mitoxantrone

44 citations , August 1996 in “Drugs & Aging”

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

research Compilation of a Comprehensive Gene Panel for Systematic Assessment of Genes That Govern an Individual’s Drug Responses

13 citations , October 2010 in “Pharmacogenomics”

Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.

Development of a Non-Parametric Population Pharmacokinetics Model and Bayesian Estimator for Tacrolimus in Tunisian Renal Transplant Patients

research Development of a Non-Parametric Population Pharmacokinetics Model and Bayesian Estimator for Tacrolimus in Tunisian Renal Transplant Patients

March 2017 in “Fundamental & Clinical Pharmacology”

The model and estimator can predict drug exposure in kidney transplant patients well.

research Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases

3 citations , December 2022 in “Cells”

Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.