From Male PCOS to Male Endocrine-Metabolic Syndrome: A Gender-Neutral Hypothesis

    August 2026 in “ Frontiers in Endocrinology ”
    Maurizio Nordio, Daniele Barbaro, Valdemaro Pavacci
    Studysummary This article proposes reclassifying certain endocrine-metabolic symptoms in men as male Endocrine-Metabolic Syndrome rather than male PCOS, but this remains a research-oriented hypothesis with no established clinical diagnosis.
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    Research cited in this study 5

    1. A Different Approach to PCOS: Evaluation of Spermiogram Results in Male Patients With a Family History of PCOS Gynecological Endocrinology · 2025
    2. Evidence From Men for Ovary-Independent Effects of Genetic Risk Factors for Polycystic Ovary Syndrome The Journal of Clinical Endocrinology and Metabolism · 2021
    3. Hormonal Effects on Hair Follicles International journal of molecular sciences · 2020
    4. Male Equivalent Polycystic Ovarian Syndrome: Hormonal, Metabolic, and Clinical Aspects DOAJ (DOAJ: Directory of Open Access Journals) · 2020
    5. Does a Male Polycystic Ovarian Syndrome Equivalent Exist? Journal of Endocrinological Investigation · 2017