Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF
March 2017
in “Nature Communications”
TLDR Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.
Macrophages play a crucial role in hair follicle regeneration by activating Lgr5+ stem cells through the AKT/β-catenin pathway and TNF. Targeting macrophages and TNF could be a potential therapeutic strategy for hair loss and alopecia. TNF is necessary for hair follicle regeneration and activates hair follicle stem cells through the AKT/β-catenin signaling pathway. The study used mice to observe these findings.
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