Synthesis and Characterization of Inclusion Complex of the Vasodilator Drug Minoxidil with β-Cyclodextrin

April 2008 in “ Journal of Inclusion Phenomena and Macrocyclic Chemistry ”

Adriana Calderini, Francisco B. T. Pessine

minoxidil β-cyclodextrin inclusion complex vasodilator solubility wettability biodisponibility Rogaine

Studysummary This study identified a weak interaction between minoxidil and ß-cyclodextrin in solution, forming an inclusion complex with a 1:1 molar ratio.

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The study synthesized and characterized an inclusion complex of minoxidil with β-cyclodextrin. The results showed the formation of a 1:1 complex between the two components, with a weak interaction in solution. The encapsulation of minoxidil with β-cyclodextrin is believed to increase its solubility and wettability, leading to a supported and gradual release of the drug and maximizing its biodisponibility over time.

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Research cited in this study

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research Minoxidil-Containing Dosage Forms: Skin Retention and After-Rinsing Hair-Growth Promotion

24 citations , January 2003 in “Drug Delivery”

This study found that only minoxidil encapsulated in cationic vesicles significantly promoted hair growth in mice, likely due to its higher retention on the skin.

research Minoxidil

5 citations , January 1988 in “Analytical profiles of drug substances”

Minoxidil helps lower blood pressure and can also promote hair growth.