Lymphomatoid Papulosis Improving on Hormone-Replacement Therapy

The document reports a case where lymphomatoid papulosis (LP), a condition characterized by benign clinical behavior but malignant histological appearance, showed improvement with hormone-replacement therapy (HRT) in a 52-year-old female patient. The patient had a history of LP since 1980, which persisted with more than 100 lesions at a time, each lasting 1–3 months. Conventional treatments such as photochemotherapy, antibiotics, topical corticosteroids, and low-dose oral methotrexate had been ineffective. The patient experienced a marked improvement in LP lesions after starting HRT in 2001 for postmenopausal symptoms. A flare occurred after stopping HRT in 2004, but upon restarting HRT, the LP cleared completely when the patient was accidentally given twice the dose in December 2006. When the HRT dose was corrected, LP returned but was less severe. This case is notable as there are no documented reports of LP clearance with HRT in the literature, suggesting that HRT at a higher dose resulted in complete suppression of LP and some suppression at a lower dose.