Lymphomatoid Granulomatosis: Case Study and Treatment

November 1992 in “ Journal of the American Academy of Dermatology ”

Melinda M. Tong, Bridget E. Cooke, R S Barnetson

cicatricial alopecia cyclophosphamide prednisone cutaneous lesions skin biopsies

TLDR Early diagnosis and aggressive treatment are crucial for better outcomes in lymphomatoid granulomatosis.

Lymphomatoid granulomatosis, also known as angiocentric T-cell lymphoma, was a systemic disease with a poor prognosis, primarily affecting the lungs and often presenting with cutaneous lesions in 40%-45% of cases. Early diagnosis through skin biopsies by dermatologists was crucial. A case study of a 42-year-old man with cutaneous lesions and cicatricial alopecia showed significant improvement with cyclophosphamide and prednisone treatment. The disease had a high mortality rate (70%-90%) and could evolve into malignant lymphoma, making early, aggressive therapy essential for better outcomes. The document also discussed the disease's link to Epstein-Barr virus and a rare case of HPV type 6 infection in a 9-year-old girl with atopic dermatitis and asthma.

View this study on jaad.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 13 results

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Finasteride not working isnt it MPB?

in Finasteride/Dutasteride 5 upvotes 6 months ago

A user is concerned that finasteride isn't working for their hair loss, questioning if it's due to male pattern baldness or low iron levels. They are advised to take finasteride daily and get blood work done.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Wanted to say that Derma rolling and Pumpkin seed oil helped my crown out.

in Treatment 4 upvotes 5 years ago

Derma rolling, pumpkin seed oil, and daily massages helped regrow weak hairs on the crown. Nizoral shampoo and yoga also contributed to reducing scalp pain and stress.

community DHT is about to get smashed ….

in Update 807 upvotes 2 months ago

The conversation discusses hair loss treatments like topical finasteride with minoxidil, oral dutasteride, and essential oils. Oral treatments like dutasteride and finasteride are seen as more effective, though some prefer topicals to avoid side effects.