Lymphomatoid Granulomatosis: Case Study and Treatment

November 1992 in “ Journal of the American Academy of Dermatology ”

Melinda M. Tong, Bridget E. Cooke, R S Barnetson

cicatricial alopecia cyclophosphamide prednisone cutaneous lesions skin biopsies

TLDR Early diagnosis and aggressive treatment are crucial for better outcomes in lymphomatoid granulomatosis.

Lymphomatoid granulomatosis, also known as angiocentric T-cell lymphoma, was a systemic disease with a poor prognosis, primarily affecting the lungs and often presenting with cutaneous lesions in 40%-45% of cases. Early diagnosis through skin biopsies by dermatologists was crucial. A case study of a 42-year-old man with cutaneous lesions and cicatricial alopecia showed significant improvement with cyclophosphamide and prednisone treatment. The disease had a high mortality rate (70%-90%) and could evolve into malignant lymphoma, making early, aggressive therapy essential for better outcomes. The document also discussed the disease's link to Epstein-Barr virus and a rare case of HPV type 6 infection in a 9-year-old girl with atopic dermatitis and asthma.

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community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 6 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Totally confused by doctors opinions, would appreciate some clarity

in Treatment 1 upvotes 2 months ago

The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

community Finasteride not working isnt it MPB?

in Finasteride/Dutasteride 5 upvotes 10 months ago

A user is concerned that finasteride isn't working for their hair loss, questioning if it's due to male pattern baldness or low iron levels. They are advised to take finasteride daily and get blood work done.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Crown and hairline thinning almost 2 years on dutasteride

in Finasteride/Dutasteride 10 upvotes 2 years ago

The user has been using minoxidil, dutasteride, and microneedling for hair loss but has noticed accelerated thinning at the crown and hairline recently. They plan to start using Nizoral and have a dermatologist appointment soon.