<i>Malassezia</i> Display a Hyphae-like “Spaghetti-and-Meatballs” Configuration in Keratotic Plugs

January 2022 in “ Medical Mycology Journal ”

Otomi Cho, Mizuki Unno, Keita Aoki, Masako Takashima, Takashi Sugita

Malassezia restricta Malassezia globosa Malassezia hyphae pityriasis versicolor keratotic plugs fungal microbiome hyphae blastoconidia

In a study analyzing the fungal microbiome of keratotic plugs from the noses of 10 healthy individuals, Malassezia restricta was identified as the predominant species, followed by Malassezia globosa. Notably, Malassezia hyphae, which were previously observed mainly in lesional sites of patients with pityriasis versicolor, were found in 5 of the 10 healthy individuals. These hyphae displayed a unique "spaghetti-and-meatballs" configuration, characterized by curved, thick-walled hyphae and spherical, thick-walled blastoconidia.

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