Low-temperature pulverization-specific <i>Sargassum horneri</i> extract accelerates wound healing and attenuates inflammation in a mouse burn model

September 2024 in “ Animal Cells and Systems ”

Eunguk Shin, Hee-Tae Kim, Haksoo Lee, Byeongsoo Kim, Junhyeong Park, Sujin Park, Soomin Yum, Seul-Kee Kim, Jae‐Myung Lee, BuHyun Youn

Sargassum horneri low-temperature pulverization F-actin reactive oxygen species pro-inflammatory cytokines

The study explores the effects of low-temperature pulverization-specific Sargassum horneri extract (LPSHE) on burn wound healing and inflammation in a mouse model and human keratinocyte cells. LPSHE was found to accelerate wound healing by promoting F-actin formation, reducing reactive oxygen species (ROS) levels, and decreasing pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α. It also enhanced cell viability, proliferation, and migration in human keratinocyte cells, while activating the FAK signaling pathway. The research underscores the potential of LPSHE as a therapeutic candidate for burn wound healing and highlights the significance of low-temperature pulverization in discovering novel marine-derived compounds.

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