Effect of a Low Insulinemic Diet on Clinical, Biochemical, and Metabolic Outcomes in Women with Polycystic Ovary Syndrome

The study investigated the effects of a low insulinemic diet on women with PCOS, involving 24 participants aged 18-45 with a BMI between 25 and 45 kg/m² over an 8-week period. The diet led to significant reductions in weight, BMI, fat mass, hip and waist circumference, fasting and 2-hour insulin levels, triglycerides, VLDL, free and total testosterone, and vitamin D levels. HDL levels decreased, while fat oxidation increased. Improvements were also noted in binge eating behaviors and quality of life, as measured by the Binge Eating Scale and PCOS-specific questionnaire. These findings suggested that a low insulinemic diet could positively impact anthropometric, biochemical, and metabolic outcomes, as well as psychological well-being in women with PCOS.