Loose Anagen Syndrome And Loose Anagen Hair

October 1996 in “ Dermatologic Clinics ”

Vincent W. Li, Howard P. Baden, Joseph C. Kvedar

Loose Anagen Syndrome anagen hairs root sheaths keratinization cell adhesion molecules autosomal dominant pattern

Studysummary This article discusses loose anagen syndrome, highlighting its characteristics, diagnostic methods, and spontaneous improvement over time, but provides no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.

The document from 1996 describes Loose Anagen Syndrome, a condition more common in young girls, where anagen hairs can be easily plucked due to a lack of root sheaths. It often leads to sparse, thin, and patchy hair without scarring or inflammation. Diagnosis involves examining plucked hairs, which show anagen phase hairs with poor attachment to the shaft. The condition may be hereditary with an autosomal dominant pattern and is thought to be caused by abnormal keratinization or alterations in cell adhesion molecules. While it tends to improve after adolescence, there is no specific treatment except for gentle hair handling. Further research is needed to understand the underlying mechanisms of the syndrome.

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research New Familial Association Between Ocular Coloboma and Loose Anagen Syndrome

19 citations , April 1995 in “Clinical Genetics”

This report describes two siblings with a new familial association of loose anagen syndrome and ocular coloboma, despite unaffected parents and no family history.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

130 citations , January 1994 in “Differentiation”

In this study, researchers found that bulge cells in mouse hair follicles undergo transient proliferation during early anagen, indicating their role as follicular stem cells. However, another factor beyond dermal papilla proximity may be required to initiate a new anagen phase.

research Clinical and Laboratory Evaluation of AIDS Trichopathy

35 citations , January 1993 in “International Journal of Dermatology”

In this study, most hair disorders among HIV-1 positive patients were associated with low helper T cell counts, with papulosquamous conditions like seborrheic dermatitis and psoriasis being the most common.

research Loose Anagen Hair as a Cause of Hereditary Hair Loss in Children

55 citations , October 1992 in “Archives of Dermatology”

In this study, researchers observed that loose anagen hair syndrome is an autosomal dominant disorder characterized by abnormal hair follicle structure and premature keratinization, possibly due to signaling and desmosomal component disturbances.

research Loose Anagen Hair of Childhood: The Phenomenon of Easily Pluckable Hair

85 citations , February 1989 in “Journal of The American Academy of Dermatology”

This case report describes a newly identified condition called loose anagen hair of childhood, characterized by easily pluckable hair in two young boys, with variable duration and no scalp inflammation or scarring.

research A Stain for Plucked Anagen Hairs

17 citations , August 1979 in “Journal of The American Academy of Dermatology”

This study found that a histochemical stain using 4-dimethyl-aminocinnamaldehyde effectively distinguishes between plucked anagen and telogen hairs by causing the root ends of anagen hairs to develop a red color.