The Role of LncRNAs in Radio- and Chemoresistance of Glioblastoma: Prognostic or Therapeutic?

This review highlights the critical role of long non-coding RNAs (lncRNAs) in the radio- and chemoresistance of glioblastoma, a type of malignant brain tumor. LncRNAs are deregulated in tumors and influence cell proliferation, cell cycle arrest, and metastasis, acting as either tumor promoters or suppressors. They are differentially expressed in tumors compared to healthy tissue, making them potential therapeutic targets and biomarkers. The review emphasizes the need for further research into the specific roles of lncRNAs in therapy resistance and their involvement in various pathways, which could improve early diagnosis and treatment outcomes for brain cancer.