The Role of LncRNAs in Radio- and Chemoresistance of Glioblastoma: Prognostic or Therapeutic?

This review explores the significant role of long non-coding RNAs (lncRNAs) in the radio- and chemoresistance of glioblastoma, a highly aggressive brain tumor. LncRNAs are crucial in modulating gene expression and signaling pathways, contributing to therapy resistance and tumor progression. They interact with microRNAs and influence pathways such as MAPK/ERK, PI3K/AKT, and Wnt/β-catenin. Specific lncRNAs like HOTAIR, LINC00461, and SNHG12 are linked to poor prognosis and treatment resistance. The review suggests that targeting these lncRNAs could improve treatment outcomes by overcoming resistance mechanisms, emphasizing the need for further research to integrate lncRNAs into clinical practice for better management of malignant brain tumors.