Lichen Planopilaris Treated With Thalidomide

December 2001 in “ Journal of the American Academy of Dermatology ”

Saira George, Sylvia Hsu

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Studysummary This case report details significant hair regrowth in a patient with lichen planopilaris after treatment with thalidomide, suggesting its potential as a treatment option for this condition.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

A 41-year-old woman with lichen planopilaris, a form of scarring alopecia, showed significant hair regrowth after being treated with oral thalidomide, following unsuccessful treatments with steroids and hydroxychloroquine. Thalidomide, known for its anti-inflammatory effects, demonstrated potential as a treatment for lichen planopilaris, similar to its effects in related conditions like lichen planus and lupus erythematosus-associated alopecia. Despite its risks, thalidomide may offer a powerful alternative for severe cases unresponsive to conventional therapies. The patient experienced hair regrowth within 1 month of treatment, but was lost to follow-up after 18 months.

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research Clinical and Immunologic Parameters During Thalidomide Treatment of Lupus Erythematosus

64 citations , May 2000 in “International Journal of Dermatology”

This study found that thalidomide increased peripheral lymphocyte counts and reduced inflammation in lupus erythematosus patients, but was associated with polyneuropathy, suggesting careful use in refractory cases.