Lichen Planopilaris Treated With Thalidomide

    December 2001 in “ Journal of the American Academy of Dermatology ”
    Saira George, Sylvia Hsu
    TLDR Thalidomide significantly improved hair regrowth in a woman with lichen planopilaris.
    A 41-year-old woman with lichen planopilaris, a form of scarring alopecia, showed significant hair regrowth after being treated with oral thalidomide, following unsuccessful treatments with steroids and hydroxychloroquine. Thalidomide, known for its anti-inflammatory effects, demonstrated potential as a treatment for lichen planopilaris, similar to its effects in related conditions like lichen planus and lupus erythematosus-associated alopecia. Despite its risks, thalidomide may offer a powerful alternative for severe cases unresponsive to conventional therapies. The patient experienced hair regrowth within 1 month of treatment, but was lost to follow-up after 18 months.
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