Levodopa-Induced Skin Disorders in Patients with Parkinson's Disease: A Systematic Literature Review

In the systematic literature review analyzing 30 studies with 2,749 patients, the authors found that malignant melanoma was the most frequent skin disorder associated with levodopa treatment in Parkinson's disease patients, followed by various other skin conditions. However, the evidence did not robustly support a causal relationship between levodopa therapy and the induction or progression of malignant melanoma. The association may be more related to Parkinson's disease itself rather than the medication. Peripheral edema was the most common skin complication in clinical trials. The review called for more well-designed prospective studies to clarify the relationship between levodopa and skin disorders, advising caution with levodopa use in the context of malignant melanoma until more definitive evidence is available.