Intracrine Testosterone Activation in Human Pancreatic Beta-Cells Stimulates Insulin Secretion

August 2020 in “ Diabetes ”

Weiwei Xu, Lina Schiffer, M.M. Fahd Qadir, Yan-Qing Zhang, James P. Hawley, Paula Mota de Sa, Brian G. Keevil, Hongju Wu, Wiebke Arlt, Franck Mauvais-Jarvis

testosterone dihydrotestosterone DHT estradiol E2 5α-reductase inhibitors aromatase inhibitors androgen excess β-cell dysfunction sex steroids 5-alpha reductase inhibitors beta-cell dysfunction sex hormones

Studysummary This study found that testosterone enhances insulin secretion in human pancreatic islets by being converted into DHT and E2, processes that are necessary for this effect.

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