Effects of KISS1 Structural Polymorphism on the Risk of Polycystic Ovary Syndrome and Reproductive Hormones in Iraqi Women Taking Metformin

September 2023 in “ Journal of International Medical Research ”

Ali Hakem Kadhem, Ashraf Gholizadeh, Mohammad Khalaj‐Kondori

TLDR Metformin increases FSH levels in PCOS, and KISS1 gene variations may influence PCOS development.

The study investigated the effects of metformin and kisspeptin structural polymorphism on polycystic ovary syndrome (PCOS) in Iraqi women. It found that metformin treatment significantly increased follicle-stimulating hormone (FSH) levels in women with PCOS. A specific single nucleotide polymorphism (G to C) in the KISS1 gene was associated with PCOS, and the C allele was linked to lower FSH concentrations after treatment. Additionally, kisspeptin concentrations decreased significantly following metformin therapy. The findings suggest that variations in the KISS1 gene may play a role in PCOS development, and metformin response could aid in early diagnosis and treatment of PCOS.

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