Keratosis follicularis spinulosa decalvans: a family study of seven male cases and six female carriers.

The document reports on a family study of Keratosis follicularis spinulosa decalvans (KFSD), an X-linked disease, involving seven male patients and six female carriers. The study focused on the dermatological and ophthalmic markers of KFSD. In male patients, the disease manifested as follicular hyperkeratosis, hyperkeratosis of the soles' calcaneal regions, scarring alopecia of the scalp, loss of eyebrows and eyelashes, and corneal dystrophy with photophobia. An additional symptom identified was high cuticles on the fingernails, which had not been previously described. Female carriers exhibited milder symptoms, including dry skin, minimal follicular hyperkeratosis, mild hyperkeratosis of the soles, and in one case, mild corneal dystrophy without photophobia.