Association Between Keloids and Atopic Dermatitis: A Cross-Sectional Study at a Tertiary Care Center

    May 2019 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Amarachi Eseonu, Raveena Khanna, A. Basirat, Donald A. Glass, Shawn G. Kwatra
    TLDR Keloids are strongly linked to atopic dermatitis and other health issues.
    This study assessed the association between keloids and atopic dermatitis in a diverse patient population using data from the Johns Hopkins Hospital System. Among 4,877,856 patients, 3,527 were diagnosed with keloids, with a significant proportion being black (59.51%). Keloids were strongly associated with atopic dermatitis (OR 16.11, p <0.0001) and asthma (OR 6.11, p<0.0001). Additionally, patients with keloids had increased likelihoods of hypertension, chronic hepatitis, HIV infection, diabetes mellitus type 2, chronic kidney disease, and ischemic heart disease. The study suggested mast cell overactivity as a potential mechanism and recommended further research into the association between keloids and atopy.
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