Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan

    July 2018 in “ BMJ Open
    Ying‐Yi Lu, Chun‐Ching Lu, Weiwen Yu, Li Zhang, Qingrui Wang, Cong-Liang Zhang, Chieh‐Hsin Wu
    TLDR People with atopic dermatitis have a higher risk of developing keloids, especially women, those under 40, and those with severe symptoms.
    The nationwide retrospective cohort study in Taiwan found that patients with atopic dermatitis (AD) had a significantly higher risk of developing keloids, with a 3.19-fold increase compared to those without AD. The study included 8,371 patients with AD and 33,484 controls, revealing that the risk was particularly elevated in females, individuals under 40, and those with moderate to severe AD. The research suggested that common pathways, possibly involving the ADAM33 gene, might contribute to both conditions. Despite limitations such as potential coding errors and lack of detailed personal risk factor information, the study highlighted the need for further research to explore causal mechanisms and validate these findings.
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