Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes

    February 2001 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Mayumi Komine, Laxmi Rao, Irwin M. Freedberg, Marcia Simon, Vladana Milisavljevic, Miroslav Blumenberg
    TLDR Interleukin-1 increases keratin K6 production in skin cells.
    The study demonstrated that interleukin-1 (IL-1) induced the transcription of keratin K6 in human epidermal keratinocytes, leading to increased K6 protein and mRNA levels. This effect was specific to IL-1 and was mediated through the C/EBPβ transcription factor. The induction was time and concentration dependent, occurring only in confluent keratinocytes, and was enhanced by epidermal growth factor or tumor necrosis factor-α. The study used various experimental techniques, including transfection of HeLa cells and electrophoretic mobility shift assays, to confirm these findings. The results suggested that IL-1 plays a significant role in cutaneous inflammation and wound healing by regulating keratin gene expression.
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