TLDR Injectable biostimulators can improve skin by boosting collagen and fat cell activity, but more research is needed to confirm their safety and effectiveness.
The document reviews the use of injectable biostimulatory agents like PLLA, PCL, and CaHA in regenerative aesthetics, focusing on their ability to stimulate collagen production and adipocyte activity, which improves skin volume, elasticity, and texture. PLLA is noted for its long-term effects on dermal thickness and elasticity, while PCL acts as a scaffold for stem cells, enhancing adipogenesis and dermal remodeling. CaHA provides immediate volumization with long-term benefits. Despite promising results, the review highlights the need for standardized protocols and large-scale studies to confirm the efficacy and safety of these treatments in aesthetic applications.
July 2024 in “Dermatological Reviews” PRP, exosomes, and stem cells show promise in improving skin and hair conditions but need standardized treatment protocols.
3 citations
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November 2021 in “Clinical, Cosmetic and Investigational Dermatology” Platelet-Rich Plasma may improve skin health and reduce wrinkles, but more research is needed for standard treatment guidelines.
387 citations
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May 2019 in “International Journal of Molecular Sciences” Adipose-derived stem cells are promising for regenerative medicine due to their accessibility, versatility, and low risk of immune rejection.
132 citations
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January 2017 in “International Journal of Molecular Sciences” Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.
10 citations
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August 2020 in “Indian Journal of Plastic Surgery/Indian journal of plastic surgery” Hyaluronic acid filler injections are a favored non-surgical method to improve facial aging signs due to their convenience, effectiveness, and durability.
February 2026 in “Journal of Cutaneous and Aesthetic Surgery” Most emerging dermatological treatments lack strong evidence and require more research.
February 2026 in “Plastic and Aesthetic Research” Regenerative aesthetic medicine aims to restore tissue function, but needs more consistent evidence and standardized practices.
3 citations
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June 2025 in “Preprints.org” Aesthetic medicine is focusing more on patient needs and using new technologies, but ethical issues and regulation challenges need attention.
2 citations
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March 2025 in “Otolaryngologic Clinics of North America” Nonsurgical facial treatments are becoming more popular due to their natural-looking results and minimal invasiveness.
