In Vitro and In Vivo Assessment of Metabolic Drug Interaction Potential of Dutasteride with Ketoconazole
December 2019
in “Pharmaceutics”
TLDR Taking Dutasteride with Ketoconazole can increase Dutasteride's effects and side effects.
In 2019, a study was conducted to investigate the potential interaction between Dutasteride, a drug used for treating hair loss, and Ketoconazole, an antifungal medication. The research was conducted both in vitro and in vivo. The results showed that co-administration of Dutasteride and Ketoconazole led to a significant increase in the systemic exposure of Dutasteride, suggesting that Ketoconazole inhibits the metabolism of Dutasteride, which could potentially lead to increased side effects. The study also developed a high-performance liquid chromatography with fluorescence detection (HPLC-FL) method for simultaneous determination of Dutasteride and its major active metabolite, 6β-hydroxydutasteride (H-DUT). The pharmacokinetics of Dutasteride and H-DUT were significantly altered by the co-administration of Ketoconazole. This was the first study to show the drug interaction potential of Dutasteride with azole antifungal drugs including Ketoconazole.
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