In-Silico Studies on the Phytochemicals Contained in Mentha Spicata for the Management of PCOS

November 2025 in “ Journal of Complementary and Alternative Medical Research ”

Kuseme Umoyo, Queensley Eghianruwa

Mentha spicata spearmint phytochemicals Polycystic Ovary Syndrome PCOS androgen receptor insulin receptor oleanolic acid

TLDR Oleanolic acid in spearmint may help manage PCOS symptoms.

This study investigates the potential of phytochemicals in spearmint (Mentha spicata) for managing Polycystic Ovary Syndrome (PCOS) through molecular docking analysis. The research focused on key proteins associated with PCOS, such as androgen receptor and insulin receptor. The analysis identified oleanolic acid as having the best binding affinity across these proteins, suggesting it may effectively target PCOS-related proteins and help reduce symptoms. However, these findings are computational, and further in vitro and in vivo studies are necessary to confirm the results.

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