TLDR The new method makes finasteride cheaper and easier to produce.
The document described an improved synthesis method for finasteride, a drug used to treat benign prostatic hyperplasia. The synthesis was achieved through a seven-step process starting from 4-androsten-3,17-dione, resulting in an overall yield of 20.01%. The improvements made the process less expensive and more commercially viable compared to previous methods reported in the literature.
14 citations
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May 2005 in “Steroids” A new method was developed to make finasteride for treating hair loss.
19 citations
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December 2019 in “Steroids” Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.
20 citations
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February 2002 in “Expert Opinion on Therapeutic Patents” New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.
2 citations
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September 2009 in “Hormone Molecular Biology and Clinical Investigation” Low dose finasteride decreases certain steroids, possibly increasing depression risk.
17 citations
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June 2012 in “European journal of medicinal chemistry” New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.