Impact of metformin and rosiglitazone treatment on glucose transporter 4 mRNA expression in women with polycystic ovary syndrome.
June 2008
in “European journal of endocrinology”
TLDR Metformin and rosiglitazone both improved insulin use and hormonal symptoms in women with PCOS.
The study from 2008 examined the impact of metformin and rosiglitazone on glucose transporter 4 (GLUT4) mRNA expression in 35 women with polycystic ovary syndrome (PCOS), with 33 completing the trial. After 6 months of treatment, both drugs significantly increased GLUT4 mRNA expression in adipose tissue, with rosiglitazone showing a more pronounced effect. Improvements were also seen in insulin resistance, as indicated by the Homeostasis Model Assessment (HOMAIR) score, menstrual bleeding frequency, and serum total testosterone levels. The study concluded that both metformin and rosiglitazone enhance clinical, hormonal, and metabolic parameters in PCOS patients, with neither drug proving superior. Further research was suggested to explore the mechanisms of these treatments and their efficacy in different patient subgroups.
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Cited in this study
research Metformin or Antiandrogen in the Treatment of Hirsutism in Polycystic Ovary Syndrome
Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.
research Polycystic Ovary Syndrome
PCOS is a common hormonal disorder causing irregular periods and increased hair growth, linked to insulin resistance and long-term health issues.