Immortalization of Primary Human Dermal Papilla Cells by Bmi-1 and TERT
September 2017
in “
Journal of Investigative Dermatology
”
hair care products HIROX quantitative image analysis hair surface roughness topical application Stemoxydine Resveratrol hair density fermented mackerel oil hair growth hair-fiber lengths dermal papilla cells wnt/ß-catenin signaling mackerel fermented fish oil UVB-induced oxidative stress human keratinocyte cells immortalization TERT Bmi-1 de novo hair follicles FMO FFO UVB DPCs
Studysummary This study reported that introducing the TERT and Bmi1 genes into mouse dermal papilla cells resulted in immortal cells capable of inducing new hair follicles in vivo, and human immortal DPCs were also developed. Our plain-language summary of this paper — not a Tressless recommendation.
The document presents several abstracts related to hair and skin research. Abstract 286 describes a study where 23 female subjects used hair care products for 4 weeks, and the roughness of their hair was measured using HIROX quantitative image analysis. The study found a significant decrease in hair surface roughness after product use. Abstract 288 reports on a study with 79 women aged 25 to 55 who used a topical application of 5% Stemoxydine® and 0.25% Resveratrol for 6 to 12 weeks, resulting in a significant increase in hair density. Abstract 290 investigates the effects of fermented mackerel oil (FMO) on hair growth, showing that FMO significantly increased hair-fiber lengths and the proliferation of dermal papilla cells (DPCs), suggesting the activation of wnt/ß-catenin signaling as a mechanism. Abstract 287 explores the protective effects of mackerel fermented fish oil (FFO) against UVB-induced oxidative stress in human keratinocyte cells. Lastly, abstract 289 discusses the immortalization of primary human dermal papilla cells using the genes TERT and Bmi-1, which led to the induction of de novo hair follicles in vivo. Abstract 291 is marked as withdrawn and does not provide any data.
