TLDR Decreased IGF-1R expression may contribute to sacrococcygeal pilonidal sinus development.
This study examined the role of Insulin-Like Growth Factor 1 Receptor (IGF-1R) in sacrococcygeal pilonidal sinus (PS) by analyzing tissue samples from 20 patients. Results showed that PS tissues had thinner epidermis, deteriorated hair follicles, and reduced IGF-1R expression in basal keratinocytes compared to healthy tissues. These findings suggest that decreased IGF-1R expression may contribute to PS development, indicating a potential area for further research into treatment options involving IGF-1R.
205 citations,
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January 2009 in “Elsevier eBooks” Hair growth is influenced by hormones and goes through different phases; androgens can both promote and inhibit hair growth depending on the body area.
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51 citations,
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