Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus

This study examined the role of Insulin-Like Growth Factor 1 Receptor (IGF-1R) in sacrococcygeal pilonidal sinus (PS) by analyzing tissue samples from 20 patients. Results showed that PS tissues had thinner epidermis, deteriorated hair follicles, and reduced IGF-1R expression in basal keratinocytes compared to healthy tissues. These findings suggest that decreased IGF-1R expression may contribute to PS development, indicating a potential area for further research into treatment options involving IGF-1R.