Investigation of Insulin-Like Growth Factor 1 Receptor Expression in Cases of Sacrococcygeal Pilonidal Sinus

June 2023 in “ Medical records-international medical journal ”

S Avci, Sevinç Şahin, Cemre Nur Balcı

Insulin-Like Growth Factor 1 Receptor IGF-1R epidermis hair follicles basal keratinocytes

TLDR Decreased IGF-1R expression may contribute to sacrococcygeal pilonidal sinus development.

This study examined the role of Insulin-Like Growth Factor 1 Receptor (IGF-1R) in sacrococcygeal pilonidal sinus (PS) by analyzing tissue samples from 20 patients. Results showed that PS tissues had thinner epidermis, deteriorated hair follicles, and reduced IGF-1R expression in basal keratinocytes compared to healthy tissues. These findings suggest that decreased IGF-1R expression may contribute to PS development, indicating a potential area for further research into treatment options involving IGF-1R.

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