Formulation and Application of a Human Insulin-Like Growth Factor 1-Loaded Transfersomal System to Enhance Skin Wound Healing in Diabetic Rat Models

    February 2026 in “ International Journal of Nanomedicine ”
    Fahimeh Nojoki, Kianoush Dormiani, Mahboobeh Forouzanfar, Amin Derakhshan, Mohammad Hossein Nasr-Esfahani, Sanaz Sedghi Esfahani, Parto Nasri
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    Studysummary This study found that controlled release of hIGF-1 from TF/hIGF-1 effectively enhanced re-epithelialization and granulation tissue formation in diabetic wounds in animal models compared to controls, suggesting a promising approach for diabetic wound treatment. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated the use of a human Insulin-Like Growth Factor 1 (hIGF-1) loaded transfersomal system (TF/hIGF-1) to enhance skin wound healing in diabetic rat models. The results showed that hIGF-1 released from the system in a controlled manner significantly promoted re-epithelialization and granulation tissue formation in diabetic wounds compared to controls. This suggests that the TF/hIGF-1 system could be a promising and effective approach for treating diabetic wounds.
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