Skin-Inspired and Self-Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy

The study presents a novel hydrophobic hydrogel, QL@MAB, designed for diabetic wound therapy. This hydrogel is composed of hydrophobic methyl acrylate and (3-acrylamidophenyl)boronic acid, co-loaded with antioxidant quercetin and antibiotic levofloxacin. The hydrogel mimics skin structure, with hydrophobic segments forming a dense "epidermis" for prolonged drug diffusion and water retention, while glucose-labile "sweat pores" facilitate drug release in hyperglycemic conditions. In diabetic rats, QL@MAB promotes rapid wound healing, angiogenesis, hair follicle regeneration, and extracellular matrix remodeling, showcasing its potential as a multifunctional dressing for diabetic wounds.