Skin-Inspired and Self-Regulated Hydrophobic Hydrogel for Diabetic Wound Therapy

    March 2025 in “ Advanced Materials ”
    Yonghang Liu, Xiaoxue Yang, Kefan Wu, Jun Feng, Xian Zhang, Ao Li, Chong Cheng, Yi Zhun Zhu, Hui Guo, Xiaolin Wang
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    TLDR The hydrogel helps heal diabetic wounds quickly and effectively.
    The study presents a novel hydrophobic hydrogel, QL@MAB, designed for diabetic wound therapy. This hydrogel is composed of hydrophobic methyl acrylate and (3-acrylamidophenyl)boronic acid, co-loaded with antioxidant quercetin and antibiotic levofloxacin. The hydrogel mimics skin structure, with hydrophobic segments forming a dense "epidermis" for prolonged drug diffusion and water retention, while glucose-labile "sweat pores" facilitate drug release in hyperglycemic conditions. In diabetic rats, QL@MAB promotes rapid wound healing, angiogenesis, hair follicle regeneration, and extracellular matrix remodeling, showcasing its potential as a multifunctional dressing for diabetic wounds.
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