A Hybrid Hydrogel Encapsulating Human Umbilical Cord Mesenchymal Stem Cells Enhances Diabetic Wound Healing
July 2022
in “
Journal of Materials Science: Materials in Medicine
”
TLDR A new hydrogel with stem cells from the human umbilical cord speeds up healing in diabetic wounds.
The study developed a hydrogel from gelatin methacrylate and chitosan-catechol to encapsulate human umbilical cord-mesenchymal stem cells (hUMSCs) for treating full-thickness diabetic wounds. The optimal hydrogel was 10% GelMA, which improved hUMSCs adhesion, proliferation, and differentiation in vitro. The hUMSCs, when used with the optimized hydrogel, accelerated the diabetic wound healing process, including faster wound closure, reduced secretion of inflammatory factors TNF-α and IL-1β, and increased vascular regeneration and collagen deposition. This suggests that the optimized hydrogel encapsulating hUMSCs could be a promising treatment for diabetic complications.
